An overview of cards collaborative atorvastatin diabetes study. We aimed to assess the effectiveness of atorvastatin 10 mg daily for primary prevention of major cardiovascular events in patients with type 2. Statins and glycaemic control in individuals with diabetes. Pdf primary prevention of cardiovascular disease with. Type 2 diabetes is associated with a substantially increased risk of cardiovascular disease, but the role of lipidlowering therapy with statins for the primary prevention of cardiovascular disease in diabetes is inadequately defined. Aspenatorvastatin study for prevention of coronary heart disease endpoints in noninsulindependent. The current study suggests that the risk of developing diabetes is limited to patients who are already at high risk. An overview of cards collaborative atorvastatin diabetes. In a metaanalysis combining published data from 47 trials in 128 601. The trial was stopped 2 years earlier than planned because of significant benefit at the second interim analysis. The effects of lowering ldl cholesterol with statin therapy in people. Apolipoproteins, cardiovascular risk and statin response. July 21 issue 1 report a lack of benefit from therapy with 20 mg of atorvastatin among patients with type 2 diabetes mellitus who were receiving hemodialysis.
The collaborative atorvastatin diabetes study cards is the only diabetesspecific primary prevention trial performed. Collaborative atorvastatin diabetes study listed as cards. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes cards overview 1 a multicenter randomized placebo controlled trial to determine hard outcomes of atorvastatin 10mg vs. Based on these findings, physicians will have to weigh risks versus benefits before prescribing statins, said dr. A case report of dyslipidemia management in newonset type. Effect of atorvastatin on creactive protein and benefits for. Al powers, director of the division of diabetes, endocrinology and metabolism at. The diabetes atorvastatin lipid intervention dali study have reported that either 10 or 80 mg of atorvastatin is equally effective in the treatment of diabetic dyslipidemia 15. Atorvastatin, cardiovascular disease, cards, creactive protein, ldlcholesterol, statins, type 2 diabetes. Esceas guidelines for the management of dyslipidemias. Collaborative atorvastatin diabetes study american. Cost effectiveness of atorvastatin in patients with type 2. Should all diabetic patients be treated with a statin.
Design of the collaborative atorvastatin diabetes study. It acts both by reducing the production of cholesterol and increasing its rate of removal from the body. The collaborative atorvastatin diabetes study cards randomized placebocontrolled trial. Patients with type 2 diabetes and no prior cvd n 2,838. Atorvastatin reduced major cardiovascular disease events.
Reduction in cardiovascular events with atorvastatin in. Pdf there are few data on the role of lipid lowering in the primary prevention of coronary. Baseline characteristics in the collaborative atorvastatin. A multicenter study in malaysia to determine the efficacy. The collaborative atorvastatin diabetes study cards is a multi. The aim of the collaborative atorvastatin diabetes study cards was to assess the effectiveness of 10 mg of atorvastatin daily versus placebo in the primary prevention of cardiovascular disease in patients with type 2 diabetes. Costeffectiveness of primary prevention of cardiovascular.
Atorvastatin in patients with type 2 diabetes mellitus. Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes. An analysis from the collaborative atorvastatin diabetes study cards author links open overlay panel helen m. Baseline characteristics in the collaborative atorvastatin diabetes study cards in patients with type 2 diabetes. The clinical benefit of use of statins in patients with type 2 diabetes has been demonstrated in several randomized, controlled trials, including the cards clinical trial. Atorvastatin reduced cv events even in low ldl dm patients.
Other calculators combine a general and a diabetesspecific approach. An overview of cards collaborative atorvastatin diabetes study primary prevention of cardiovascular disease with atorvastatin in type 2. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. A multicenter study in malaysia to determine the efficacy and safety of a generic atorvastatin n punithavathi, dch, l m ong, frcp, y l l lena, msc, s leekha, md, on behalf of the storvas clinical trial study group clinical research centre, penang hospital, residency road 10990 pulau pinang, malaysia, ranbaxy malaysia sdn bhd original. Colhoun hm, betteridge dj, durrington pn, hitman ga, neil ha, livingstone sj, thomason mj, mackness mi, charltonmenys v, fuller jh 2004. Patients with type 2 diabetes mellitus have a high risk of developing cardiovascular cv disease. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of pre. Teaching and learning taught masters after you graduate taught masters download a prospectus taught masters admissions process taught masters fees for taught masters study.
Atorvastatin in new onset type 1 diabetes mellitus t1dm. The minor increase in blood glucose with statins may be enough to push atrisk. The care trial randomized 4,159 patients from 80 centres across canada and the united states. Abstract background there are few data on the role of lipid lowering in the primary prevention of coronary heart disease chd in diabetic. Atorvastatin is a drug used to lower high levels of cholesterol and other fatlike substances in the blood. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the collaborative atorvastatin diabetes study cards. One in 4 americans 40 years of age takes a statin to reduce the risk of. A landmark lipitor study of patients with type 2 diabetes.
Register, 7 look ahead action for health in diabetes, 8 addition anglodanishdutch study of intensive treatment in people with screen detected diabetes in primary care, 9 cards collaborative atorvastatin diabetes study. In summary, this trial supports the use of statin therapy to lower cholesterol levels patients with known coronary heart disease and ldl levels 125 mgdl. Ppt atorvastatin clinical study program powerpoint. Safety of atorvastatin in the collaborative atorvastatin diabetes study cards the safety and efficacy of sta the safety and efficacy of statins for cvd prevention is well established, yet some physicians have concerns about the longterm safety of this class. Combining ezetimibe with a statin reduces ldlc by an additional. Cards study design collaborative atorvastatin diabetes study. Atorvastatin, cardiovascular disease, cards, creactive protein, ldl cholesterol, statins, type 2 diabetes. Colhoun hm, betteridge dj, durrington pn, hitman ga, neil ha, livingstone sj, charltonmenys. Study comparing pitavastatin and atorvastatin in patients. Safety of atorvastatin in the collaborative atorvastatin. It is given by mouth to people who have hypercholesterolaemia high cholesterol levels in the blood.
Combining ldlcholesterol and crp ontreatment categories. An analysis based on the uk prospective diabetes study ukpds risk engine. Pdf design of the collaborative atorvastatin diabetes study. These joint esceuropean atherosclerosis society eas guide lines on the. Study cards, 2,838 subjects with type 2 diabetes who did not have established cardiovascular disease were randomly assigned to receive atorvastatin or placebo 11. Collaborative atorvastatin diabetes study cards 2838 primary prevention patients no ascvd with type 2 diabetes at least 1 other cv risk factor such as smoking, hypertension, retinopathy, or microalbuminuria ldlc levels. Following study termination the data will be merged with. Atorvastatin reduced major cardiovascular disease events in type 2 diabetes mellitus colhoun hm, betteridge dj, durrington pn, et al. Design of the collaborative atorvastatin diabetes study cards. Highdose atorvastatin was linked to a 37 percent increased diabetes risk, the study found. Based on the clinical cards data, the favourable cost effectiveness of atorvastatin 10mg in.